Imazio M1, et al. ICAP Investigators. N Engl J Med. 2013 Oct 17;369(16):1522-8.
This multicentre double-blind RCT found that a 3 month course of low-dose colchicine is superior to placebo in reducing recurrence rates after first-episode pericarditis (NNT 4, ARR 0.2, RRR 0.56). The group felt that colchicine should be considered in first-episode pericarditis, but raised concerns about the cost of the drug for patients with no drug coverage. By: Dr. Christa Dakin
Epi lesson: Data Safety Monitoring Boards