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Efficacy and safety of colchicine for treatment of multiple recurrences of pericarditis (CORP-2): a multicentre, double-blind, placebo-controlled, randomised trial.

Chest X-ray of calcific pericarditisMethodology Score:    4/5                   
Usefulness Score:  4/5

Imazio M, et al.
Lancet. 2014 Jun 28;383(9936):2232-7.


This randomized double-blind placebo-controlled trial of colchicine in addition to usual anti-inflammatory therapy for the treatment of recurrent pericarditis showed an impressive relative risk reduction of 0.49 (95% CI 0.24-0.65) for subsequent recurrence over the 18+ month follow-up period. JC attendees had some difficulty with applying these results to ED patients as this was not an ED-specific trial, but felt overall that colchicine would be useful in the rare instances that these patients present primarily to the ED, as long as cardiology follow-up was in place.
By: Dr. Christa Dakin
(Presented November) 2014


Epi lesson:  Flow Diagram    
Investigators and editors developed the CONSORT Statement (revised 2010 http://www.consort-statement.org/home/) to improve the reporting of randomized controlled trials (RCTs) by means of a checklist and flow diagram. The flow diagram is intended to depict the passage of participants through an RCT and depicts numbers and explanations from four stages of a trial (enrollment, intervention allocation, follow-up, and analysis). The diagram explicitly shows the number of participants, for each intervention group, included in the primary data analysis.

By: Dr. Ian Stiell

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