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Air Versus Oxygen in ST-Segment–Elevation Myocardial Infarction

"Zuurstofleiding" by Harmid - Own work. Licensed under Public Domain via Wikimedia Commons - Score: 3.5/5              
Usefulness Score: 3.5/5

Stub D, Smith K, Bernard S, et al.
Circulation. 2015 Jun 16;131(24):2143-50. 

Oxygen for ST-Segment–Elevation Myocardial Infarction: Still Up in the Air
Nedeljkovic ZS, Jacobs AK.
Circulation. 2015;131:2101-2103

There is no good existing evidence to support the use of O2 in non-hypoxic STEMI patients, particularly in the era of PCI, and there is a growing body of evidence to suggest harm.  This paper makes a good attempt to answer the question definitively, but is not powered to do so in a clinically relevant way.  Take home points are 1) remember that O2 is still a drug, and that indiscriminate use has potential for harm, and 2) stay tuned for the Hoffman study (DETO2X-AMI) next year to possibly answer this clinical question.  
By: Dr. Thara Kumar
(Presented December 2015)

Epi Lesson: What is a Geometric Mean?
A geometric mean is a type of mean or average which can be useful when combining items measured on a different scale. It is obtained by calculating the square root of the product of 2 numbers rather than dividing their sum. If we take the example of a survey where one answer is “3” on a 5-point Likert scale and another answer is “7” on a 10-point Likert scale, the usual/arithmetic “mean answer” would be (3+7)/2=5 whereas the geometric mean would be √(3x7)=4.6…which is slightly less influenced by the magnitude of the answer measured on a 10-point Likert scale.  
By: Dr. Christian Vaillancourt


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