Journal Club Summary
Epi lesson:Surrogate endpoints
Can be used as a measure of effect for specific treatments and might correlate with clinical outcomes. In the RE-VERSE AD (idarucizumab for dabigatran reversal) study the investigators used dilute thrombin time and ecarin clotting time as surrogate end points for reversal of dabigatran action by the study drug idarucizumab. The actual clinical end point of restoration of hemostasis was a secondary outcome. This was a small study. We need a large clinical study with a control group to confirm that clinical outcomes among patients treated with the reversal agent were better. Be wary of studies using surrogate outcomes when clinical outcomes could have been used.
By: Dr. Venkatesh Thiruganasambandamoorthy