Skip to main content

Naproxen With Cyclobenzaprine, Oxycodone/ Acetaminophen, or Placebo for Treating Acute Low Back Pain A Randomized Clinical Trial

Journal Club Summary

Methodology Score: 3.5/5              
Usefulness Score: 3.5/5

Friedman BW, et al.
JAMA. 2015;314(15):1572-1580.

In this pragmatic 3-arm RCT of Naproxen + placebo or cyclobenzaprine or acetaminophen/oxycodone for acute low back pain, there was no significant difference in the primary outcome of improvement in pain and functional scores at one week following discharge from the ED. The methodology of this study was quite robust, however the small sample size, lack of adherence to the investigational medications, and narrow selection criteria limit its applicability to our population.
By: Dr. David Gruber

Epi lesson:

Multiple Imputation for Missing Data
When analyzing data from a dataset, most statistical software can only include cases where data is available for each of the included predictive variables. When data is missing for one or several important predictive variables, analysts have the option to “impute” the missing data. One simple strategy is to replace the missing information with the “mean” from the rest of the available data. Multiple imputation is a more complex strategy which replaces each missing value with a set of plausible values, which includes a level of uncertainty about the right value to impute. Important considerations include if data is missing at random, and how much data is missing.
By: Dr. Christian Vaillancourt

Comments

Popular posts from this blog

Tips for Success in your Emergency Medicine Rotation

Our wonderful medical students are preparing to start their first clinical rotations. With this in mind here are some of the top tips for success in your EM rotation
1)Be On Time – show up to your shifts on time, better yet 5 minutes early.That first impression is immensely important.
2)Introduce yourself to the team - “Hi my name is John Doe, I am the medical student on shift today” introduce yourself to the attending, residents, nurses, etc.You will be called on a lot more to help when there is something interesting going on if they know your name.
3)Be goal-oriented – have a goal for each shift, whether it’s a procedure or a type of presentation to see.
4)Don’t just stand there, do something – whenever there is a trauma or code, come to the bedside.Get gowned up for traumas and pay attention.Help with things that are within your scope of practice: chest compressions, moving patient, cardioversion
5)Don’t just stand there, do nothing – there are times in medicine when the best thing to d…

2014 Canadian Guidelines for AF Management: Part 1: Introduction and CCS “CHADS-65” Algorithm

by Ian Stiell MD @EMO_Daddy














In this and subsequent postings we will discuss the latest recommendations for ED management of atrial fibrillation (AF) as presented in the newly published 2014 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation. The Guidelines PDF can be downloaded from the CCS website at 2014 Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation
The 2014 Focused Update uses the GRADE system of evidence evaluation as was the case in the comprehensive 2010 AF Guidelines and the 2012 Update. The CCS AF Guidelines Panel is comprised of Canadian cardiologists plus physicians from internal medicine, family medicine, neurology, and emergency medicine. This 2014 Update provides evidence review and recommendations for 8 aspects of AF care, including ED Management (written by myself and Dr. Laurent Macle of the Montreal Heart Institute). The 2014 Update focuses on advances in oral anticoagulant (O…

You CAN reverse that! Reversal of NOAC's and more..

We have seen a large surge of the utilization of New Oral Anticoagulants (NOAC's) in the past few years, as such, it has been a novel challenge when these patients present to the Emergency Department (ED) with life threatening bleeding. Dr. Michael Ho looks to discuss treatment options, and future options in these patients. 
NOACs vs WarfarinDabigatran, Rivaroxaban and Apixaban have seen a dramatic increase in use since their approval in Canada. Dabigatran is a direct thrombin (Factor II) inhibitor, while the latter two are direct Xa inhibitors. These drugs are collectively referred to as novel oral anticoagulants (NOACs). They have also been called direct, or target-specific oral anticoagulants (DOACs or TSOACs) [1]. 
The NOACs have many practical advantages over warfarin: Rapid onset of actionShorter half-lifeLess food and drug interferencePredictable pharmacokineticsEase of use and no requirement for monitoringThe downsides to NOACs are the higher cost to the patient, the inabilit…