Emergency department-initiated buprenorphine/naloxone treatment for opioid dependence: a randomized clinical trial
D'Onofrio G, et al
JAMA. 2015 Apr 28;313(16):1636-44.
By: Dr. Isabelle Miles
All intervention studies should indicate how the sample size was estimated including the desired alpha error (usually 0.05), power (usually 80-90%), and expected outcome rate in the control group. Most important is a statement of the minimal clinically important difference (MCID) that would have to be shown by the study intervention for clinicians to accept the new treatment as better. In an effort to keep sample size low, investigators sometimes estimate an MCID much larger than is reasonable.
By: Dr. Ian Stiell